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PILOREM 80/10/25 TABLETS

Anti-hypertensive

Telmisartan 80mg and Amlodipine 10mg and Hydrochlorothiazide 25mg

PACKET SIZE - 30

PILOREM-HCT comes as a fixed dose tablet of amlodipine 10mg/telmisartan 80mg/hydrochlorothiazide 25mg in a pack of 30 tablets in alu-alu satchets for better storage PILOREM-HCT is a combination of Amlodipine, Telmisartan and Hydrochlorothiazide. Telmisartan plus Amlodipine plus Hydrochlorothiaziade is a synergistic combo: angiotensin receptor antagonist/blocker plus calcium channel blocker plus diuretic. One tablet to be taken once daily with light meal.

SIDE EFFECTS

The combination of low dose Amlodipine and Ramipril significantly reduces cough associated with the use of ramipril through inhibition of PG synthesis ( Forgari, R et al (91999). Other SIDE EFFECTS include hypotension, Acute Hepatitis, Angiodema, headache

PILOREM 80/10 TABLETS

Anti-hypertensive

Telmisartan 80mg and Amlodipine 10mg

PACKET SIZE - 30

PILOREM comes as a fixed dose tablet of amlodipine 10mg/telmisartan 80mg in a pack of 30 tablets in alu-alu satchets for better storage PILOREM is a combination of Amlodipine and Telmisartan. Telmisartan plus Amlodipine is a synergistic combo: angiotensin receptor antagonist/blocker plus calcium channel blocker. Telmisartan is an effective dose of 20-80mg while amlodipine is effective in dose of 2.5-10mg. Dosage must be individualized and may be increased after at least 2 weeks. Most of the antihypertensive effect is apparent after 2 weeks and maximal reduction is generally attained after 4 weeks. The maximum recommended dose of PILOREM tablets is 80/10mg once daily.

SIDE EFFECTS

Peripheral oedema, dizziness, headache, orthostatic hypotension, syncope, fatigue and back pain, exacerbation of angina; myocardial infarction; hyperkalemia

PILOREM 40/5 TABLETS

Anti-hypertensive

Telmisartan 40mg and Amlodipine 5mg

PACKET SIZE - 30

PILOREM comes as a fixed dose tablet of amlodipine 5mg/telmisartan 40mg PILOREM is a combination of Amlodipine and Telmisartan. Telmisartan plus Amlodipine is a synergistic combo: angiotensin receptor antagonist/blocker plus calcium channel blocker. Telmisartan blocks the effects of angiotensin 2 in the vascular smooth muscle and the adrenal gland, lowering the BP. It is 42-58% absorbed following oral administration; metabolized by the liver; excreted unchanged in feaces and has a T1/2 of about 24hrs. Telmisartan is an effective dose of 20-80mg while amlodipine is effective in dose of 2.5-10mg. Dosage must be individualized and may be increased after at least 2 weeks. Most of the antihypertensive effect is apparent after 2 weeks and maximal reduction is generally attained after 4 weeks. The maximum recommended dose of PILOREM tablets is 80/10mg once daily.

SIDE EFFECTS

Peripheral oedema, dizziness, headache, orthostatic hypotension, syncope, fatigue and back pain, exacerbation of angina; myocardial infarction; hyperkalemia

MARCSON DIHYDROARTEMISININ AND PIPERAQUINE

Malaria Infection

DIHYDROARTEMISININ AND PIPERAQUINE

PACKET SIZE - 9's

It comes as a pack of 9 tablets( 40/320) and 80ml suspension (80/640) Interferes the membrane structure of the trophozoite, leading to dissociation of ribosomes leading to autophagocytosis. In the treatment of uncomplicated Plasmodium falciparum malaria. Children(by weight), 5kg, 10.5ml daily for 3 days, 7.5kg 16ml daily for 3 days, 10kg 21ml daily for 3 days, 15kg 31.5ml daily for 3 days. Adult; 10-14years 2 tablets daily for 3 days, 15 years and above 3 tablets daily for 3 days.

SIDE EFFECTS

Tachycardia, QT elongation, headache, anemia.

COLIBEL ORAL DROPS

Infant anticolic

Simethicone 40mg

PACKET SIZE - 30ml.

COLIBEL DROP comes as a solution of 30ml. Each ml contains simethicone emulsion equivalent to simethicone 40mg syrup base flavoured with Dill oil BP and Fennel oil BP. It acts as an antifoaming agent to reduce flatulence. Its silicon polymer lower surface tension and allows small bubbles to coalesce to larger ones that can easily passed up. Used for the relief of excess gas in digestive tract, infantile colic, gripping pain, abdominal discomfort. infants( below 6 months) 0.3-0.7ml q.d.s 15min before feed, 6-12 months 0.7-1.3ml q.d.s 15mins before feed, over 1 year, 1.3ml q.d.s 15mins before feed.

SIDE EFFECTS

COLIBEL DROP is physiologically inert.

GYNOMARC KIT TABLETS

Antibiotic

Fluconazole/Scenidazole/Azithromycin

PACKET SIZE - 100's

GYNOMARC KIT is a combination of Fluconazole, Azithromycin and secnidazole. A pack contain one white tablet ( Fluconazole 150mg), one orange caplet(Azithromycin 1gram) and 2 yellow caplets( Secnidazole 1gram each) Fluconazole eradicates Candida albicans, Secnidazole eradicates the protozoa Trichomonas vaginalis while Azithromycin eradicates N. gonorrhoeae and C. trachomatis Syndromic management of vaginal discharge The whole content of GYNOMARC KIT ( Fluconazole 150mg, Azithromycin 1 gram, Secnidazole 2gram) as single dose

SIDE EFFECTS

Nausea, dyspepsia, headache, pseudomembrane colitis

MARCDERM TRIVALENT CREAM

Anti- Ecematous

Clobetasol + Miconazole + Gentamicin

PACKET SIZE - 20g

MARCDERM TRIVALENT is a dermatologist’s and medical practitioner’s go to medication for various skin conditions. It contains a fine blend of clobetasol, miconazole, gentamicin and zinc oxide. Clobetasol is a powerful corticosteroid of super high potency compared to bethamethasone, dexamethasone. Apply thin layer and rub into the affected area twice daily

SIDE EFFECTS

Burning, redness, dryness

TANDAFLAM TABLETS

Analgesic/Anti-inflammatory

Diclofenac potassium 50mg

PACKET SIZE - 100's

TANDAFLAM is a brand of diclofenac potassium comes as 50mg tablet, packed as 100 tablets in a pack TANDAFLAM is an NSAID which acts by inhibition of COX enzyme. TANDAFLAM is indicated in osteoarthritis, rheumatoid and low back pain. Also used in migraine, ankylosing sondilytis. 100mg daily in 2 divided doses.

SIDE EFFECTS

Nausea, diarrhoea, slight transaminase increase, rash, headache.

FLOMARC

Antibiotic

Ofloxacin

PACKET SIZE - 14's

FLOMARC comes as 200mg tablet in a pack of 14 FLOMARC is a floroquinolone which has broad spectrum of activity against gram-positive and gram-negative bacteria by inhibiting DNA gyrase preventing bacteria multiplication. In terms of pharmacokinetic activity, FLOMARC is superior to the likes of ciprofloxacin with more rapid absorption and higher peak serum concentration. 200mg twice daily for 5-7 days or single dose of 400mg in uncomplicated urethral and cervical gonorrhoea

SIDE EFFECTS

Ranges from GIT symptoms like nausea, vomiting, dyspepsia, diarrhoea to skin rash and hypersensitivity reactions to skin, acute anaphylaxis

MARCREX INJECTION

Anti-Heamorrhagic

Tranexamic acid BP

PACKET SIZE - 5's

MARCREX is a brand of tranexamic acid injection, comes as 500mg colourless liquid filled in a glass ampoule. MARCREX injection is a competitive inhibitor of plasminogen activation and at much higher concentrations, a noncompetitive inhibitor 0f plasmin i.e action similar to aminocaproic acid. The antifibrinolytic activity of Marcrex is about 10times more potent in vitro than aminocaproic acid. Posology Adult Unless otherwise prescribed, the following doses are recommended: 1.Standard treatment of local fibrinolysis: 0.5g(1 ampoule of 5ml) to 1g(1 ampoule of 10ml or 2 ampoule of 5ml) tranexamic acid by slow intravenous injection(=1ml/minute) two to three times daily. 2.Standard treatment of general fibrinolysis: 1g(1 ampoule of 10ml or 2 ampoules of 5ml) tranexamic acid by slow intravenous injection(=1ml/minute) every 6 to 8 hours, equivalent to 15mg/kg

SIDE EFFECTS

Diarrhoea, vomiting, nausea, allergic dermatitis. Hypotension has been observed when intravenous injection is too rapid

MARCGESIC TABLETS

Analgesic/muscle relaxant

Paracetamol + Orphenadrine

PACKET SIZE - 100's

MARGESIC contain paracetamol 450mg/orphenadrine 35mg. It comes as a pack of 20’s and 100’s Orphenadrine is an anti-cholinergic drug used to treat pain caused by muscle injuries like sprains, strains as well as headaches. It is a muscle relaxant that exerts its effect by acting centrally to elicit anticholinergic effect. Paracetamol is an analgesic that exert its action by prostaglandin inhibition in CNS and peripheral blocking of impulse. Two tablets taken 3-4 times daily.

SIDE EFFECTS

Dry mouth, urinary urgency, constipation and mental confusion. Hypersensitivity reactions like skin rash, hepatitis, tachycardia, insomnia are rare.

MARCRICH TONIC

Haematinic

Iron + Folic acid + Vit. B12 + Lysine

PACKET SIZE - 200ml

PRESENTATION:- MARCRICH TONIC contains iron choline citrate, folic acid, vitamin B12 USP and L-Lysine monohydrochloride, all in flavoured palatable base with caramel color. PHARMACOLOGICAL ACTION:- Iron maintains healthy red blood cells and therefore assists with the transport of oxygen throughout the body. Cyanocobalamin and folic acid help cell metabolism, DNA synthesis and haemopoiesis. Deficiencies of both Cyanocobalamin and folic acid are common due to dietary inadequacies and particularly to infants born to mothers who are grossly deficient in folate or vitamin B12 during pregnancy. Supplementation of both folic acid and Cyanocobalamin is therefore necessary in such cases to prevent nutritional megaloblastic anaemia. Lysine provides dietary supplement, increasing appetite and weight gain in children. INDICATIONS:- MARCRICH TONIC is indicated for; -The treatment of common iron deficiency anaemia due to chronic blood loss, inadequate intake of iron, hook-worm infestation etc - Dimorphic anaemia due to deficiency of iron, folic acid and/ or vitamin B12 - Anaemia of pregnancy and lactation - Increased iron demand during convalescence from prolonged illness and other debilitating conditions - Anaemia due to excessive or repeated haemorrhage, post-surgical conditions and others - To provide dietary supplementation for rapid growth and weight gain in children and also for improving general metabolism

SIDE EFFECTS

Side effects include epigastric pain, nausea, vomiting, abdominal cramp, diarrhoea and constipation may occur in patients. Stools may darken in color with iron.

MARCFIX SUSPENSION

Antibiotic

Cefixime 50mg + Clavulanic acid 12.5mg

PACKET SIZE - 10's

MARCFIX suspension comes as powder suspension of 50mg cefixime/31.25mg clavulanate MARCFIX is a superior combination of cefixime and clavulanic acid. Cefixime is a first line third generation broad spectrum cephalosporin. Clavulanic acid is a B-lactamase inhibitor with proven efficiency over the years MARCFIX is indicated in RTI, UTI, Gonococcal urethritis, pre/post- operative treatment. 400mg daily in single or two divided dose(adult), 8mg/kg in single or two divided dose ( 6 month-12years)

SIDE EFFECTS

GI effects like nausea, diarrhoea, and others, dizziness, fatigue

MARCFIX TABLETS

Antibiotic

Cefixime 200mg + Clavulanic acid 125mg

PACKET SIZE - 10's

MARCFIX comes as film coated tablet of 200mg cefixime//125mg clavulanate MARCFIX is a superior combination of cefixime and clavulanic acid. Cefixime is a first line third generation broad spectrum cephalosporin. Clavulanic acid is a B-lactamase inhibitor with proven efficiency over the years 400mg daily in single or two divided dose(adult), 8mg/kg in single or two divided dose ( 6 month-12years)

SIDE EFFECTS

GI effects like nausea, diarrhoea, and others, dizziness, fatigue

TANDAK INJECTION

Injection

Injection 1.5g

PACKET SIZE - 1

PRESENTATION:- TANDAK is a fixed dose combination of ceftriaxone and sulbactam. TANDAK comes as 1gram and sulbactam 500mg in a via PHARMACOLOGICAL ACTION:- Ceftriaxone is a first line third generation cephalosporin that has broad spectrum of activity against gram positive and gram negative bacteria and long serum half life compared to other third generation agents. Sulbactam is a B-lactamase inhibitor that irreversibly bind to the B-lactamase. This action prevents the enzyme from hydrolysing the ceftriaxone. TANDAK has a lower MIC compared to ceftriaxone alone making it ideal in geriatrics and kidney compromised patients
INDICATIONS:- TANDAK is indicated in skin and soft tissue infection, otitis media, gonorrhoea, syphilis, nosocomial infections caused by susceptible bacteria as well as surgical prophylaxis. TANDAK is the injectable antibiotic of choice for diagnosed and empiric treatment for PHARMACISTS, PAEDIATRICIANS, GYNAECOLOGISTS, SURGEONS. DOSAGE:- 1.5g to 3g daily or as prescribed by physician

SIDE EFFECTS

Vomiting, diarrhoea, haemolytic anaemia

MARCTHER INJECTION

Injection

3 ampoules of 2ml each. Each ml contain 75mg

PRESENTATION:- MARCTHER is a brand of Arteether. It comes in a pack of 3 ampoules of 2ml each. Each ml contain 75mg PHARMACOLOGICAL ACTION:- MARCTHER acts at the erythrocyte stage of malaria parasite. The endoperoxide functional group is responsible for the lysis of the parasite cell. INDICATIONS:- It is use in complicated and uncomplicated P.falciparum treatment, cerebral malaria and as second line treatment of chloroquine resistant malaria DOSAGE:- 150mg once daily IM for 3 days(adult), 3mg/kg once daily IM for 3 days

SIDE EFFECTS

Generally well tolerated but some effects such as dizziness, tinnitus, QT interval prolongation, convulsion may be seen

MARCNOL

amlodipine 5mg/ramipril 2.5mg and amlodipine 10mg/ramipril 5mg

PACKET SIZE - 30's

PRESENTATION:- MARCNOL comes as a fixed dose tablet of amlodipine 5mg/ramipril 2.5mg and amlodipine 10mg/ramipril 5mg in a pack of 30 tablets in alu-alu satchets for better storage PHARMACOLOGICAL ACTION:- MARCNOL is a combination of Amlodipine and Ramipril. Amlodipine is a calcium channel blocker. Amlodipine inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. Inhibition is selective, with a greater effect on vascular smooth muscle cells. Unlike the first generation dihydropyridines, it doesn’t cause reflex tachycardia. Amlodipine acts directly on vascular smooth muscle leading to a reduction in peripheral vascular resistance and a subsequent reduction in BP. Ramipril is an angiotensin converting enzyme inhibitor with a higher potency compare to lisinopril. It help with renal protection through inhibition of direct renal vasoconstriction by angiotensin .

SIDE EFFECTS

The combination of low dose Amlodipine and Ramipril significantly reduces cough associated with the use of ramipril through inhibition of PG synthesis ( Forgari, R et al (91999). Other side effect include hypotension, Acute Hepatitis, Angiodema, headache

DABIC

7.5mg and 15mg

PACKET SIZE - 10

PRESENTATION:- DABIC is a brand of meloxicam. It comes in an alu-alu pack of 10 tablets. DABIC has two strengths 7.5mg and 15mg PHARMACOLOGICAL ACTION:- It acts by preferentially inhibiting COX-2 to elicit its anti-inflammatory and analgesic effects. This preferential actions makes it the drug of choice over acetylsalicylate, piroxicam, ibuprofen, mefenamic acid. DABIC is also preferred over selective COX-2 inhibitors ( CELECOXIB, RAFECOXIB) due to the severe cardiovascular effect they pose INDICATIONS:- DABIC is used for acute exacerbation of osteoarthritis(short term), ankylosing spondyllitis. DOSAGE:- 7.5mg daily, increased to maximum 15mg

SIDE EFFECTS

Oedema, hypertension, nausea, GI irritation and bleeding

AMTEPINE

Injection

it comes as a pack of 6 ampoules of 1ml each. It comes in two strengths, 40mg and 80mg.

PACKET SIZE - 6

PRESENTATION:- AMTEPINE injection is a brand of Artemether. It comes as a pack of 6 ampoules of 1ml each. It comes in two strengths, 40mg and 80mg.
PHARMACOLOGICAL ACTION:- AMPTEPINE is a blood schizonticide and used for treatment of multiple resistant strains of P.falciparum.
Compared to quinine in preventing deaths from severe malaria, shorter recovery time from malaria induced coma
by shortening parasite clearance time and brain damage(cochane library- pubmed publication 2014)
INDICATIONS:- AMPTEMINE is indicated in all forms of plasmodium including severe malaria DOSAGE:- 3.2mg/kg body weight
is administered as single dose first day, followed by 1.6mg/kg for the next four days

SIDE EFFECTS

Transient ECG changes, increase in transaminase, tinnitus

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